B Positive

Drew, a newly divorced dad, is overwhelmed by health worries and mounting bills when a chance encounter with Gina, a blunt and streetwise woman from his past, leads to an extraordinary agreement. She offers to donate a kidney, and the two strike up an unlikely partnership built on humor, stubbornness, and shared optimism. What begins as a practical arrangement gradually reveals a surprising connection that challenges both of them to rethink their lives. The show mines the awkwardness and warmth of two very different people learning to trust each other, as they handle doctor visits, clinics, and the everyday chaos of ordinary life. The tone stays grounded even when the jokes turn sharp, letting tiny victories feel earned and everyday quirks become endearing.

Created by Marco Pennette, B Positive debuted in 2020 on CBS as part of the networks half hour comedy slate. It's a workplace and family comedy about an unlikely partnership formed under unusual health circumstances, anchored by Annaleigh Ashford and Thomas Middleditch.

Reception has been mixed, with audiences responding to its warm humor and earnest look at organ donation and second chances. Viewers praise the chemistry between Ashford and Middleditch, and the balance of laugh out loud moments with genuine, quiet honesty. The show centers on Gina and Drew and uses humor to soften heavier themes about family, friendship, and generosity.

While not a cultural blockbuster, B Positive contributed to a trend of heartwarming comedies that address real life issues with sensitivity. The pairing of Ashford and Middleditch gave viewers memorable moments that highlighted generosity and chosen kinship. Its title signals an optimistic take on health and relationships, and it sparked online conversations about organ donation in casual, hopeful terms.

Awards The show did not receive major nominations or wins during its run, and it remained a modest ratings performer. Critics and fans tended to praise the cast's chemistry and the warmth of the writing, rather than pursue awards. The series found its audience in family friendly, hopeful humor.