Common Side Effects poster

Common Side Effects

TV Show 2025 8.4 /10
Created by Steve Hely, Joseph Bennett, Jon Foor

Marshall Cuso and Frances Applewhite, once top partners in a high school lab, reconnect as adults and stumble into a hidden conspiracy. A powerful alliance between big pharma and government agencies has quietly kept quiet a rare mushroom that could, if proven real, unlock cures for all diseases.... Read more

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Streaming availability last verified: January 14, 2026

About Common Side Effects

Marshall Cuso and Frances Applewhite, once top partners in a high school lab, reconnect as adults and stumble into a hidden conspiracy. A powerful alliance between big pharma and government agencies has quietly kept quiet a rare mushroom that could, if proven real, unlock cures for all diseases. As they chase down clues, the two friends must weigh their own safety against the chance to reveal a truth that could upend medicine, politics, and the way science is funded. The search pulls in allies and rivals alike, turning a quiet reunion into a dangerous test of trust and courage.

Common Side Effects is an original animated series created by Steve Hely, Joseph Bennett and Jon Foor released in 2025. It blends drama, comedy and speculative science, and features a voice cast led by Dave King, Emily Pendergast, Mike Judge, Martha Kelly and Joseph Lee Anderson.

The show probes ethics in science and power, asking who decides what knowledge is shared and who pays the price when cures exist but stay hidden. It pairs sharp humor with tense mystery, giving characters room to question authority while the world around them grows more surreal.

Box office data does not apply to TV series and there is no worldwide gross to report. As a streaming animated drama the series has drawn attention for its bold premise and strong ensemble performance.

Details

Release Date
February 02, 2025
User Ratings
229 votes
Type
TV Series
Seasons
2
Episodes
10
Genres
Animation, Drama, Comedy, Sci-Fi & Fantasy

Official Trailer

Cast

Dave King

Dave King

Marshall Cuso (voice)

Emily Pendergast

Emily Pendergast

Frances Applewhite (voice)

Mike Judge

Mike Judge

Rick Kruger (voice)

Martha Kelly

Martha Kelly

Agent Harrington (voice)

Joseph Lee Anderson

Joseph Lee Anderson

Agent Copano (voice)

Created by: Steve Hely, Joseph Bennett, Jon Foor

Seasons (2 seasons, 10 episodes)

Season 1

Season 1

10 episodes - 2025

Season 2

Season 2

0 episodes

Frequently Asked Questions

Common Side Effects is available to stream on Max. You can also rent or buy it on Apple iTunes, Google Play, Vudu, and Amazon Video.

Yes, Common Side Effects is available to stream on Max.

Yes, you can buy on Apple iTunes, Google Play, Vudu, and Amazon Video.

Common Side Effects has 2 seasons with a total of 10 episodes.

With a rating of 8.4/10 from 229 viewers, Common Side Effects is highly recommended and considered excellent by most viewers.

Marshall Cuso and Frances Applewhite, once top partners in a high school lab, reconnect as adults and stumble into a hidden conspiracy. A powerful alliance between big pharma and government agencies has quietly kept quiet a rare mushroom that could, if proven real, unlock cures for all diseases. ...

Common Side Effects stars Dave King, Emily Pendergast, Mike Judge, Martha Kelly, and Joseph Lee Anderson.

Common Side Effects was created by Steve Hely, Joseph Bennett, and Jon Foor.

Common Side Effects was released on February 02, 2025.

Common Side Effects is a Animation, Drama, Comedy, and Sci-Fi & Fantasy series.

Common Side Effects is an animated series that blends drama, comedy, and sci-fi. It follows former high school lab partners Marshall Cuso and Frances Applewhite as they uncover a conspiracy involving big pharma and the federal government to suppress knowledge of a rare mushroom that could cure all diseases. Dave King voices Marshall Cuso.

Dave King voices Marshall Cuso in Common Side Effects. Marshall Cuso is one of the central characters in the show.

Emily Pendergast voices Frances Applewhite in Common Side Effects. Frances Applewhite is the other lead, a former lab partner who helps uncover the conspiracy.

Common Side Effects has 2 seasons and 10 episodes in total. The series premiered in 2025 and spans a mix of Animation, Drama, Comedy, and Sci-Fi & Fantasy.