Resident Evil: Degeneration poster

Resident Evil: Degeneration

"Evil never rest"

Movie R 2008 1h 37m 6.8 /10 Fall 2008
Directed by Makoto Kamiya

In a city ravaged by a deadly virus, veteran officer Leon S. Kennedy and young fighter Claire Redfield team up to stop a revenge-seeking operative who has released the G-Virus into the streets. Their pursuit threads through collapsed neighborhoods, smoky laboratories, and crowded transit hubs as... Read more

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Streaming availability last verified: February 12, 2026

About Resident Evil: Degeneration

In a city ravaged by a deadly virus, veteran officer Leon S. Kennedy and young fighter Claire Redfield team up to stop a revenge-seeking operative who has released the G-Virus into the streets. Their pursuit threads through collapsed neighborhoods, smoky laboratories, and crowded transit hubs as they try to uncover the conspirator behind the outbreak. Along the way they collide with dangerous, mutated creatures created by the virus, forcing them to improvise gear and tactics on the fly. The duo must rely on trust and courage while the city teeters on collapse, with danger lurking around every corner. A shadowy figure from their past complicates the mission, heightening each checkpoint they reach.

Directed by Makoto Kamiya and based on Capcom's Resident Evil game series, the film arrived in 2008 as a CGI feature that translates tense game moments into high energy, visually driven chase sequences designed for a broad audience.

Among fans the movie is remembered for bringing Leon and Claire into a fully animated realm, expanding a shared universe beyond games. Its brisk visuals and familiar franchise beats make it a talking point for discussions of game to screen adaptations and CGI battles. The release helped solidify the idea that Resident Evil stories can unfold in different formats without losing core tone.

Critics noted the film moves quickly and keeps action front and center, while some found the dialogue serviceable and the adaptation solid but familiar. Core themes focus on the ethics of bioweapons, resilience under pressure, and the strength of teamwork. The balance between horror and action makes it accessible to fans and newcomers alike, though some considered it a confident but conventional entry.

Animation studio Digital Frontier; Source material Capcom's Resident Evil video game series; Notable staff Makoto Kamiya directs with Shoutarou Suga, Hiroyuki Kobayashi and Yoshiaki Hirabayashi contributing to the script. The production blends game lore with CGI action and martial pacing, delivering a film that mirrors the games' tension while standing on its own.

Details

Release Date
February 13, 2008
Runtime
1h 37m
Rating
R
User Ratings
1,148 votes
Type
Movie
Genres
Horror, Action, Science Fiction
Country
Japan
Collection
Resident Evil (Animated) Collection
Animation Studio
Digital Frontier
Based On
Video Game
Format
MOVIE
Box Office
$403,117

Official Trailer

Voice Cast

Paul Mercier

Paul Mercier

Alyson Court

Alyson Court

Laura Bailey

Laura Bailey

Roger Craig Smith

Roger Craig Smith

Crispin Freeman

Crispin Freeman

Michael Sorich

Michael Sorich

Salli Saffioti

Salli Saffioti

Michelle Ruff

Michelle Ruff

Mary Elizabeth McGlynn

Mary Elizabeth McGlynn

Steve Blum

Steve Blum

Director: Fabrizio Manfredi

Frequently Asked Questions

Resident Evil: Degeneration is not currently available on streaming subscription services, but you can rent or buy it on Apple iTunes, Google Play, Vudu, and Amazon Video.

With a rating of 6.8/10 from 1,148 viewers, Resident Evil: Degeneration is considered solid entertainment worth checking out. It's a good pick if you enjoy zombie, male protagonist, and female protagonist stories.

In a city ravaged by a deadly virus, veteran officer Leon S. Kennedy and young fighter Claire Redfield team up to stop a revenge-seeking operative who has released the G-Virus into the streets. Their pursuit threads through collapsed neighborhoods, smoky laboratories, and crowded transit hubs as ...

Resident Evil: Degeneration is adapted from a video game. The anime brings the game's story and characters to the screen with animation by Digital Frontier.

Resident Evil: Degeneration was animated by Digital Frontier.

Resident Evil: Degeneration is primarily available in Japanese with subtitles. English dubs may be available on some platforms - check the streaming options above for audio availability.

Paul Mercier voices Leon S. Kennedy in Resident Evil: Degeneration. In the film, Leon is one of the protagonists who battles the threats unleashed by the G-Virus.

Alyson Court voices Claire Redfield in Resident Evil: Degeneration. Claire is one of the central characters alongside Leon S. Kennedy.